Director / Principal Investigator
Dr. Amanpreet Badhwar is an Assistant Professor at the University of Montreal, Faculty of Medicine, Department of Pharmacology and Physiology, and a Principal Investigator at the Centre de recherche de l'Institut universitaire de gériatrie de Montréal (CRIUGM). She is a member of the Canadian Consortium on Neurodegeneration in Aging (CCNA). She is also actively engaged in several committees of the International Organization for Human Brain Mapping.
From the undergraduate to postdoctoral level, Dr. Badhwar’s path has been to study neurological disease by combining different data types, starting with small-scale genetics and brain imaging early in her career, and progressively moving to “big data” in Alzheimer’s disease (AD). Dr. Badhwar’s multi-institutional PhD work under the supervision of Professor Edith Hamel at McGill University combined the themes of multimodal research (neuroimaging, proteomics, and measures of neurovascular coupling), to tease apart the contributions of neuronal and cerebrovascular damage on cognitive dysfunction in AD, and the impact of drug treatment on these components.
Elements of Dr. Badhwar’s postdoctoral work with Professor Pierre Bellec sought to characterize the heterogeneity in AD cohorts using resting-state functional MRI connectivity, an emerging biomarker of synaptic or network dysfunction in AD. These investigations contributed to the understanding of connectivity measures in AD from three different perspectives: group-level connectivity, connectivity subtypes, and individual connectivity fingerprint.
Another important aspect of Dr. Badhwar’s postdoctoral work was focused on establishing a biomarker roadmap for the Canadian Consortium for Neurodegeneration in Aging, where she and her colleagues proposed an analytic framework for generating multiomics biomarkers from imaging, genomics, metabolomics and other modalities.
Dr. Badhwar has held several prestigious scholarships over the years, and was recently awarded the Chercheur-boursier Junior 1 from the Fonds de recherche du Québec.
Natasha joins Dr Badhwar’s MIND Lab from the UK, where she originally studied Psychology at Cardiff University and was awarded a Masters with Distinction from Swansea University. She is soon to complete her PhD at St George’s University of London, where she used machine learning to find novel signatures of early Alzheimer’s disease (AD) in spoken language, adding to the growing evidence base supporting computational assessment of speech as a biomarker test for disease.
Prior to this Natasha worked clinically and in research, including two years training as a Memory Clinic Psychologist at the Research Institute for the Care of Older People, Bath, UK. A previous winner of the Medical Research Council Max Perutz Science Writing award, Natasha is passionate about science communication. Her research at the MIND lab will use data-driven approaches to study multiomics in AD and other dementias, as a window to understanding and detecting disease.
Sabrina Loudjani is an undergraduate student at the University of Montreal, doing a major in biomedical sciences. She is very interested in conducting research in brain diseases, such as Alzheimer disease. Since 2018, Sabrina has conducted multiple internships under the supervision of Dr. AmanPreet Badhwar. With great passion and enthusiasm, she hopes to continue growing as a scientist in this field.
Steven is a student at the Engineering School of Centrale of Lyon in Machine Learning, Robotic, Probabilities and Statistics and Optimization. In parallel, he obtained his Licence in Mathematics at Claude Bernard University in Lyon, especially on Linear Algebra and Functional Analysis. He also took courses on the architecture and evolution of eukaryotic and prokaryotic genomes at Ecole Normale Supérieure of Lyon.
Recently, Steven also completed an internship at INSERM, on the study of a heterogeneous body by ultrasound echography by measuring delay aberrations. Thanks to the Mitacs Globalink scholarship, he joins Dr. Badhwar’s team during his gap year.
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Active or Long-term Collaborators
Antonio Nanci, University of Montreal, Montreal
Arsalan Haqqani, National Research Council of Canada, Ottawa
Danica Stanimirovic, National Research Council of Canada, Ottawa
David Rudko, Montreal Neurological Institute, McGill University, Montreal
Edith Hamel, Montreal Neurological Institute, McGill University, Montreal
Howard Chertkow, Baycrest Health Sciences and the Rotman Research Institute, Toronto
Jamie Near, Douglas Hospital Research Centre, McGill University, Montreal
Louis Collins, Montreal Neurological Institute, McGill University, Montreal
Miroslava Cuperlovic-Culf, National Research Council of Canada, Ottawa
Natasha Rajah, Douglas Hospital Research Centre, McGill University, Montreal
Pedro Rosa-Neto, Douglas Hospital Research Centre, McGill University, Montreal
Pierre Bellec, CRIUGM, University of Montreal, Montreal
Pierre Haddad, University of Montreal, Montreal
Ravi Rungta, University of Montreal, Montreal
Roger Dixon, University of Alberta, Edmonton
Simon Duchesne, Université Laval, Quebec City
Simona Brambati, CRIUGM, University of Montreal, Montreal
Serge Gauthier, Douglas Hospital Research Centre, McGill University, Montreal
Sridar Narayanan, Montreal Neurological Institute, McGill University, Montreal
Steffany Bennet, University of Ottawa, Ottawa
Athina Tzovara, University of Bern, Switzerland
Dan Lloyd, Trinity College, USA
Daniel Margulies, Institut de Cerveau et de la Moelle épinière-Paris, France
Felix Hoffstaedter, Forschungszentrum Jülich, Germany
Hien Nguyen, La Trobe University, Australia
Lucina Uddin, University of Miami, USA
Thomas Hinault, Inserm, France